Small-Scale Synthesis and Purification Services

Our small-scale synthesis capability is designed to produce milligram amounts (mgs to hundreds of mgs) of pure peptides, tailored to meet your precise requirements. We offer a compehensive range of services in this area. We have exemplified some aspects of our capability below (custom synthesis, fluorescent labelling, peptide-oligo hybrids, cyclic peptides, site-specific modification, peptide arrays, peptide libraries).

All peptides we synthesise are supplied as either crude material, or as HPLC-purified samples to the level you specify, for example: >80%; >90%; >95%; >99%. They are also quality-assured and quality-checked by the use of HPLC and Mass Spec (MALDI-TOF and/or electrospray). Additionally, we can offer amino acid analysis and N-terminal sequencing.If you don't see what you need here, please contact us - we have a broad capability that isn't fully detailed on the web-site. We should be pleased to discuss your precise requirements with you.

Custom Peptide Synthesis

Custom-made peptides, peptidomimetics and proteins for research use of freeze-dried material. We can supply peptides on fast turnaround times, to any level of purity to meet your needs.

Labelled Peptides For Use In Fluorescence Assays

Peptides are synthesised with suitable fluorescent labels for use in assays: kinase; protease; binding; IMAP; and FRET assays.

Peptide-Oligo Hybrids for Delivery Of Anti-Sense DNA Fragments

These compounds consist typically of a transporter peptide joined on to a cargo molecule, where the cargo molecule could for example be anti-sense DNA. Most types of dyes or tags can be incorporated, preferably at each end of the molecule. The oligo portion usually has a phosphorothioate backbone to give it stability towards enzymic degradation.

Cyclic Peptides

Peptides are typically cyclised by one of two approaches: via a disulphide bond; or by a peptide bond.

Site-Specific Modifications

Modifications at residue-specific and site-specifiic positions are introduced into peptides. For example, phosphorylation; biotinylation.

CoScan Peptide Arrays

Supplied in easy-to-use kit form, our proprietary CoScan arrays offer a high-quality, low-cost, solution for mapping experiments. For example mapping linear epitopes in antibodies and TCRs (Find out more...).

Peptide Libraries

High-throughput synthesis of complex-mixture peptide libraries (up to 1 million peptides) with amounts of 50-250 nanomoles per peptide supplied in easy-to-use kit form (96-well plates).